A NOVEL SPERM-DELIVERED TOXIN CAUSES LATE-STAGE EMBRYO LETHALITY AND TRANSMISSION RATIO DISTORTION IN C. ELEGANS.

A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans.

The evolutionary fate of an allele ordinarily depends on its contribution to host fitness.Occasionally, however, genetic elements arise that are able to gain a transmission advantage while simultaneously imposing a fitness cost on their hosts.We previously discovered one such element in C.elegans that gains a transmission advantage through a combin

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New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking

Sortase A inhibition is a well establish strategy for decreasing bacterial virulence by affecting numerous key read more processes that control biofilm formation, host cell entry, evasion and suppression of the immune response and acquisition of essential nutrients.A meta-analysis of structures known to act as Sortase A inhibitors provided the star

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